The NFL’s annual Thanksgiving tripleheader opens Week 12 of the 2023 season and we’re rounding up all of our betting experts’ top NFL Thanksgiving predictions based on the odds from our best NFL betting sites.
The NFL’s Thanksgiving tripleheader opens with the Green Bay Packers visiting the Detroit Lions for a 12:30 p.m. ET kickoff. The Dallas Cowboys and Washington Commanders will follow suit at 4:30 p.m. with the San Francisco 49ers’ visit to play the rival Seattle Seahawks wrapping up the full day of football at 8:20 p.m. ET.
To help bridge the gap to the NFL’s Sunday slate, we have our Dolphins vs. Jets predictions for the league’s first-ever Black Friday game.
Check out our best NFL Thanksgiving predictions based on the top NFL Week 12 odds and betting lines.
NFL Thanksgiving schedule and odds
Odds via bet365 as of Tuesday at 10 a.m. ET
NFL Thanksgiving predictions
Packers vs. Lions pick: Over 45.5 (-110 via FanDuel, Caesars, bet365) ⭐⭐⭐
Packers-Lions prediction made by Mike Spector.
Commanders vs. Cowboys pick: Over 48.5 (-105 via FanDuel) ⭐⭐⭐⭐
Commanders-Cowboys prediction made by Phil Wood.
49ers vs. Seahawks pick: Under 43.5 (-110 via DraftKings) ⭐⭐⭐
49ers-Seahawks prediction made by Brenden Schaeffer.
NFL expert picks for Thanksgiving
NFL betting odds pages
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